TP7 Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a structural analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro sequence that enhances its stability and metabolic half-life.Key characteristics include: Anxiolytic and Nootropic Effects: Selank is designed to provide anti-anxiety effects without sedation, cognitive impairment, or addiction potential, making it distinct from traditional anxiolytics. 2 Neurotransmitter Modulation: It enhances GABAergic signaling, increases serotonin metabolism, and modulates dopaminergic and noradrenergic tone, contributing to its nootropic effects. 2 Immunomodulatory Activity: Selank influences immune function by modulating cytokine balance and enhancing the ability of phagocytes to engulf pathogens. 2 Regulatory Approval: It received approval in Russia for the treatment of generalized anxiety disorder and as an adjunct therapy for neurasthenic conditions in 2009. 2 Selank is marketed under the brand name Selanc® as an intranasal spray and is one of the few peptides with regulatory approval for anxiety disorders. 2
